Abstract This study evaluated the technical and economic feasibility of membrane bioreactors (MBR) followed by nanofiltration (NF) for dairy wastewater treatment in order to reuse the treated effluent. It was observed that the MBR efficiently removed the organic matter and color of the feed effluent; however, due to the high concentration of dissolved solids in the permeate, it was necessary to use nanofiltration as a polishing step. The final treated effluent could be reused in the industry for cooling, steam generation and cleaning of external areas. A preliminary economic analysis showed the feasibility of the proposed system. The internal rate of return was greater than or equal to 32% when membrane lifespan was at least 2 years and the depreciation time was 15 years. The total cost of the proposed treatment system ranged from R$ 9.99/m3 to R$ 6.82/m3, depending on membrane lifespan.